I. Hub Reaction
   A. acetyl-CoA
   B. pyruvate dehydrogenase (PDH) complex
      1. size
      2. cofactors
      3. enzymes
         a. pyruvate dehydrogenase - E1
         b. dihydrolipoyl tranacetylase - E2
         c. dihydrolipoyl dehydrogenase - E3

II. Reactions
   A. Decarboxylation
   B. Oxidation
   C. formation of acetyl CoA

III.   Beriberi disease