Krebs cycle

   I. Notes
      A. Sir Hans Krebs
      B. Functions
         1. amphibolic

  II. Reactions
      A. Step 1
         1. Rxn
         2. Enzyme
         3. DeltaGų' = -7.5 kcal/mol
      B. Step 2
         1. Rxn
         2. Enzyme
            a. rxn 2a
               1) DeltaGų' = +2 kcal/mol
            b. rxn 2b
               1) DeltaGų' = -0.5 kcal/mol
      C. Step 3
         1. Rxn
         2. Enzyme
         3. DeltaGų' = -2.0 kcal/mol
      D. Step 4
         1. Rxn
         2. Enzyme
         3. DeltaGų" = -7.2 kcal/mol
      E. Step 5
         1. Rxn
            a. substrate-level phosphorylation
         2. Enzyme
            a. (alpha2 beta2) - quaternary structure
         3. DeltaGų' = -0.8 kcal/mol
         4. Note
            a.nucleoside diphosphokinase
      F. Step 6
         1. Rxn
         2. Enzyme
         3. DeltaGų' = 0
      G. Step 7
         1. Rxn
         2. Enzyme
         3. DeltaGų' = -0.9 kcal/mol
      H. Step 8
         1. Rxn
         2. Enzyme
         3. DeltaGų' = +7.1 kcal/mol

 III. Overview / Review
      A. Equation
      B. Enter & Exits
      C. Energy Totals
         1. TCA cycle
         2. Hub rxn
         3. Glycolysis
         4. Totals