Functions of CD8+  Effector T Cells                                 Chapter 11

   I. Introduction

  II. Differentiation
      A. Activation
         a. signal
            1) B7
            2) CD28
         b. signal
            1) cytokines
         c. signal
            1) CD40L - CD40
         d. licensing
      B. Effectorization

 III. CD8+ Effector Functions
      A. Synapse formation
      B. Killing
         1. overview
         2. granules
         3. contents
            a. perforin
            b. granzymes
               1) apoptosis
            c. granulysin
         4. FAS-L
            a. FAS
      C. Protection
         1. cathepsin B
         2. serine proteinase inhibitor

  IV. Exhaustion
      A. Repeated stimulation
      B. Chronicity

   V. Memory CD8+ T cells