Effector Mechanisms of Humoral Immunity Chapter 13

1. Overview
   1. humoral immunity
      1. Active immunity
      2. Passive immunity
2. How Abs work
   1. Neutralization
   2. Agglutination / precipitation
   3. Opsonization
      1. FcR
      2. Fcg
         1. FcgR1
         2. FcgRII
         3. FcgRIII
   4. ADCC
      1. NK cells
         1. FcgRIIIA
   5. Clearance of Helminths
      1. eosinophils
         1. major basic protein
      2. mast cells
3. Complement
   1. background
   2. history
   1. Classical Complement activation
      1. C1
         1. C1q, C1r, & C1s
      2. C4
      3. C2
         1. classical pathway C3 convertase
      4. C3
         1. C5 convertase
      5. C5
      6. C6 & C7
      7. C8
      8. C9
      9. MAC
   2. Alternate Complement Cascade
      1. C3b
      2. Factor B
      3. Factor D
   3. Lectin Complement Cascade
      1. MBL or ficolin
      2. MASPs
      3. Functions of complement system
      4. MAC
      5. opsonization
         1. CR1
         2. C3b & C4b
      6. inflammation
         1. C5a
      7. B cell responses
         1. C3d
            1. CR2
   4. Regulation of Complement Activation
      1. C1 inhibitor
      2. Decay-accelerating factor
      3. Factor H
      4. Factor I
      5. Membrane cofactor protein
      6. CD59
4. Evasion of Complement by Microbes