Effector Mechanisms of Humoral Immunity                     Chapter 13

   I. Overview
      A. humoral immunity
         1. Active immunity
         2. Passive immunity

  II. How Abs work
      A.Neutralization
      B. Agglutination / precipitation
      C. Opsonization
         1. FcR
         2. Fc gamma
            a. Fc gamma R1
            b. Fc gamma RII
            c. Fc gamma RIII
      D. ADCC
         1. NK cells
            a. Fc gamma RIIIA
      E. Clearance of Helminths
         1. eosinophils
            a. major basic protein
         2. mast cells

 III. Complement
             1.    background
             2.    history
      A. Classical Complement activation
         1. C1
            a. C1q, C1r, & C1s
         2. C4
         3. C2
            a. classical pathway C3 convertase
         4. C3
            a. C5 convertase
         5. C5
         6. C6 & C7
         7. C8
         8. C9
         9. MAC
      B. Alternate Complement Cascade
         1. C3b
         2. Factor B
         3. Factor D
      C. Lectin Complement Cascade
         1. MBL or ficolin
         2. MASPs
      D. Functions of complement system
         1. MAC
         2. opsonization
            a. CR1
            b. C3b & C4b
         3. inflammation
            a. C5a
         4. B cell responses
            a. C3d
               1) CR2
      E. Regulation of Complement Activation
         1. C1 inhibitor
         2. Decay-accelerating factor
         3. Factor H
         4. Factor I
         5. Membrane cofactor protein
         6. CD59

  IV. Evasion of Complement by Microbes