Innate Immunity                    Chapter 4

   I. Background
      A. Innate
      B. What do
      C. Advantages & disadvantages

  II. External Barriers
      A. Skin
      B. Mucus
      C. Other washing action
      D. Antimicrobial peptides in secretions
         1.lactoperoxidase
         2. lysozyme
         3. defensins
         4. collectins
         5. cathelicidin
         6. SLPI
      E. Gastric pH
      F. Normal flora 
      G. Tissue resident sentinel cells

 III. Phagocytosis
      A. Process
         1. phagosome
         2. phagolysosome
      B. Recognition
         1. PAMPs
         2. DAMPs
            a. alarmins
         3. PRRs
            a. Toll-like receptors
               1) name
               2) protein structure
               3) cell surface
               4) lysosomal
            b. NOD-like receptors
               1) structure
               2) subfamilies
               3) examples
                  - gout
            c. RIG-like receptor
            d. CDS
            e. Lectin receptors
      C. Killing
         1. reactive oxygen species (ROS)
         2. nitric oxide
         3. proteolytic enzymes

  IV. Humoral Mechanisms
      A. Complement
         1. alternative pathway
            a. C3
            b. C3b
            c. MAC
         2. additional Complement activities
            1) opsonization
         3. released fragments
      B. Pentraxins
            a. CRP
      C. Collectins
         1. structure
         2. family members
            a. MBL
            b. surfactant protein A & D
      D. Ficolins
         1. structure, action

   V. Inflammation
      A. Signs
      B. Purpose
      C. Initiation
      D. Process
         1. vasodilation 
            a. permeability
         2. leukocyte recruitment
            a. adhesion molecules
               1) ICAM-1
               2) selectins
            b. tumbling
            c. integrins
            d. diapedesis
         3. pus
      E. Hallmarks
         1. localized
            a. acute inflammation
         2. healing
         3. chronic inflammation
      F. Outcomes

  VI. Antiviral
      A. Interferons
         1. family,  source,  actions
      B. NK cells
         1. function / detection
         2. killing
            a. perforin
            b. granzymes -> apoptosis

 VII. Fever

VIII. Stimulating Adaptive Immune Responses
         1) adjuvants
      A. Costimulators
      B. Cytokines
      C. Complement