Immune Cell Receptor Complex Structures

1. Signal Transduction Overview
   1. Definition
      1. process
   2. Kinases
      1. tyrosine kinases
      2. serine/threonine kinases
      3. phosphatase
   3. Receptor categories
      1. non-receptor tyrosine kinases
      2. receptor tyrosine kinases (RTKs)
      3. nuclear receptors
      4. seven-transmembrane receptors = G protein-coupled receptors
      5. others
   4. Immune receptor family
      1. ITAMs
      2. ITIMs
   5. Coreceptors
2. B Cell Receptor Complex
   1. BCR
   2. Accessory molecules
   3. B cell coreceptor complex
      1. CR2
      2. CD19 & CD81
3. T Cell Receptor
   1. Overview
      1. clonally distributed
   2. ab TCR
      1. structure
         1. extracellular domain
            1. Ig-like domains
               1. variable Ig-like (V)
               2. hypervariable (CDRs)
               3. constant (C)
         2. hinge region
         3. transmembrane domain
         4. cytoplasmic domain
      2. recognition of MHC complex
         1. loops
         2. affinity
   3. CD3 and z (zeta) Proteins of the TCR Complex
      1. CD3
         1. structure
            1. extracellular
            2. transmembrane domain
            3. cytoplasmic domains
      2. z (zeta)
         1. structure
            1. extracellular domain
            2. transmembrane domain
            3. cytoplasmic domain
         2. function
         3. ZAP-70
   4. TCR summary
4. CD4 and CD8
   1. Structure
      1. CD4
      2. CD8
   2. Functions
   3. Costimulatory Receptors of T cells
5. MHC
   1. Discovery
   2. Overview
      1. Class I MHC
      2. Class II MHC
   3. Structure
      1. properties of both classes
         1. extracellular domain
            1. cleft
            2. Ig-like domain
         2. transmembrane domain
         3. cytoplasmic domain
      2. Class I MHC Molecules
         1. proteins
            1. a chain
            2. b2-microglobulin
         2. cleft
      3. Class II MHC Molecules
         1. proteins
            1. a chain
            2. b chain
         2. cleft
         3. Ig domains
   4. In the cleft
      1. peptide-MHC Interactions
      2. structural basis of binding