Immune Cell Receptor Complex Structures 

   I. Signal Transduction Overview
      A. Definition
         1. process
      B. Kinases
         1. tyrosine kinases
         2. serine/threonine kinases
         3. phosphatase
      C. Receptor categories
         1. non-receptor tyrosine kinases
         2. receptor tyrosine kinases (RTKs)
         3. nuclear receptors
         4. seven-transmembrane receptors = G protein-coupled receptors
         5. others
      D. Immune receptor family
         1. ITAMs
         2. ITIMs
      E. Coreceptors

  II. B Cell Receptor Complex
      A. BCR
      B. Accessory molecules
      C. B cell coreceptor complex
         1. CR2
         2. CD19 & CD81

 III. T Cell Receptor
      A. Overview
         1. clonally distributed
      B. alpha beta TCR
         1. structure
            a. extracellular domain
               1) Ig-like domains
                  a) variable Ig-like (V)
                     - hypervariable (CDRs)
                  b) constant (C)
            b. hinge region
            c. transmembrane domain
            d. cytoplasmic domain
         2. recognition of MHC complex
            a. loops
            b. affinity
      C. CD3 and zeta Proteins of the TCR Complex
         1. CD3
            a. structure
               1) extracellular
               2) transmembrane domain
               3) cytoplasmic domains
         2. zeta
            a. structure
               1) extracellular domain
               2) transmembrane domain
               3) cytoplasmic domain
            b. function
            c. ZAP-70
      D. TCR summary

  IV. CD4 and CD8
      A. Structure
         1. CD4
         2. CD8
      B. Functions
      C. Costimulatory Receptors of T cells

   V.  MHC
       A. Discovery
       B. Overview
          1. Class I MHC
          2. Class II MHC
       C. Structure
          1. properties of both classes
             a. extracellular domain
                1) cleft
                2) Ig-like domain
             b. transmembrane domain
             c. cytoplasmic domain
          2. Class I MHC Molecules
             a. proteins
                1) alpha chain
                2) beta2-microglobulin
             b. cleft 
          3. Class II MHC Molecules
             a. proteins
                1) alpha chain
                2) beta chain
             b. cleft
             c. Ig domains
       D. In the cleft
          1. peptide-MHC Interactions
          2. structural basis of binding