Cell Communication                 Chapter 16

   I. General Principles
      A. Signal transduction
            a. cell signaling
            b. receptors 
            c. signal transduction
      B. Forms of signaling
         1. system wide
            a. endocrine
         2. Local - only affect local cells
            a. paracrine
            b. autocrine
         3. neuronal signaling
         4. direct contact
      C. Binding Specificity
         1. effector specificity
         2. measurement
            a. dissociation constant (Kd)
      D. Cellular response

  II. Intracellular Receptors
      A. Classes 
      B. Actions
         1. direct
         2. activate transcription
            a. domain structure
            b. general mode of action
            c. homodimeric receptors
            d. cytoplasmic receptor
            e. heterodimeric receptors

 III. Cell Surface receptors
      A. Overview
           a. intracellular signaling pathway
           b. second messengers
         1. Functions
      B. Classes
         1. Ion-channel-coupled receptors
         2. G-protein-coupled receptors
         3. Enzyme-coupled receptors

  IV. Ion-channel-coupled Receptors