Muscle         Chapter 17b

   I. Background
      A. muscle fibers
      B. Prefixes
         1. Myo, Mys, Sarco
      C. Types
         1. Skeletal
         2. Cardiac
         3. Smooth

  II. Microscopic Anatomy
      A. Muscle fiber
         1. sarcolemma
         2. sarcoplasm
         3. myofibrils
      B. Bands
         1. Major bands
         2. I band
               1) Z disc
            a) sarcomere
         3. A band
               1) H zone
               2) M line
      C. Molecular Level
         1. Myosin
               1) head
               2) tail
               3) myosin filament
         2. Actin
            a. tropomyosin
               1) troponin
            b. Band formation
      D. Additional structures
         1. Sarcoplasmic Reticulum
            a. terminal cisternae
         2. T Tubules
         3. Triad

 III. Contraction = Sliding Filament Mechanism
      A. Activation
         1. motor neuron
         2. neuromuscular junction
            a. synaptic cleft acetylcholine (ACh)
               1) ACh receptors
      B. Muscle translation
         1. polarized
         2. depolarizes
      C. Muscle Contraction at the molecular level
         1. overall
         2. myosin heads
            a. attach
               1) cross bridges
            b. pivot
            c. pull 
               1) working (power) stroke
            d. release
               1) cross bridge detachment
            e. cock
         3. Notes
      D. Relaxation

  IV. Energy Specializations
      A. glycogen
      B. myoglobin
      C. creatine phosphate (phosphocreatine) (CrP)

   V. Smooth Muscle
      A. Background
      B. Microscopic structure
         1. Organization
               1) peristalsis
         2. Protein
            a. Myosin filaments
            b. Actin
            c. Intermediate filaments
            d. Dense bodies
      C. Contraction
            a. calmodulin
            b. myosin light chain kinase