Chapter 4 - Protein Structure and Function
- Introduction
- Proteins
- Shape & Structure of Proteins
- Primary structure
- aas
- peptide bonds
- ends
- naming
- peptide, polypeptides, protein
- size
- daltons - kDa
- Secondary structure
- a helix
- b sheet
- parallel
- antiparallel
- b turn
- irregular structure
- random coil
- Tertiary structure
- non-covalent bonds
- hydrophobic interactions
- disulfide bonds
- broad categories
- Quaternary structure
- homomeric
- heteromeric
- Additional Structures
- Structural motifs
- coiled-coil
- leucine rich repeats
- helix-turn-helix
- EF hand
- basic helix-loop-helix
- zinc finger
- Domains
- classes
- Fundamental classes
- Proteome
- Protein Folding
- Planar peptide bonds
- Directing protein folding
- native state
- denaturation
- Chaperones
- families
- molecular chaperones
- chaperonins
- Alternative foldingHow Proteins Work
- Binding
- ligand
- binding site
- specificity
- affinity - Kd
- Enzymes
- background
- substrates
- active Site
- example
- serine proteases
- cofactors
- metals / ions
- small organic cpds
- vitamins
- altered and replaced
- Common pathway association
- protein machines
- How Proteins Are Controlled
- Long term control
- Synthesis
- Degradation
- Location
- organelle
- membrane
- Proteolytic cleavage
- zymogens
- Short term control
- Inhibitors
- competitive
- allosteric regulation
- allosteric binding site
- feedback inhibition
- Ca++ switching
- switch proteins
- GTPase switching
- Phosphorylation
- kinase
- phosphatase