Adaptive Immunity Chapter 17

1. Antigen (Ag)
   1. Epitopes
   2. Hapten
2. Antibody (Ab)
   1. Immunoglobulin (Ig)
   2. Structure
      1. Side to side
         1. Heavy chains
         2. Light chains
      2. Top to Bottom
         1. Function
            1. Fab
            2. Fc
         2. Sequence
            1. variable region
            2. constant region
   3. Classes
      1. IgM
      2. IgG
      3. IgA
      4. IgD
      5. IgE
3. Lymphocyte Development
   1. Diversity
   2. Development
   3. Selection
      1. positive selection
      2. negative selection
      3. T lymphocytes
         1. thymus
      4. B lymphocytes
         1. bone marrow
   4. Lymphoid tissue
4. Ab production
   1. Exogenous Ags
   2. B lymphocytes
      1. bind
      2. internalize
      3. processe
      4. present
      5. waits
   3. T-Helper cells
      1. CD-4
      1. B cell Primary response
         1. clonal selection
         2. differentiation
            1. plasma cells
               1. titer
         3. class switching
         4. affinity maturation
      2. Secondary Response
         1. memory B cells
   4. T-Independent Ag
5. Ag-Ab binding results
   1. Neutralization
   2. Immobilization
   3. Agglutination & Precipitation
   4. Opsonization
   5. Complement activation
   6. ADCC
6. Cellular Immunity
   1. Endogenous
      1. MHC class I
      2. cytotoxic T cell
         1. CD 8
   2. Viral infection
      1. NK cells
7. Review