Chapter 11 - Biotechnology and medicine - Condensed version

• 11.1 Introduction
  1. 20^th Century
  2. Public health vs. clinical medicine
  3. Infectious disease vs. chronic disease
  4. Early biotech impact
• 11.2 Pharmaceuticals and biopharmaceuticals
  1. Pharmaceutical drugs
  2. Biopharmaceuticals
  3. Other impact of biotechnology
• 11.3 Antibiotics
  1. Alexander Flemming
     1. source
  2. Definition
  3. How many
  4. Introduction
  5. Spectrum
  6. Production
     1. new improvements
  7. Major applications of genetic manipulation on production
  8. Orphan drugs
  9. Resistance
  10. Animal feeds & food preservation
• 11.4 Vaccines and monoclonal antibodies
  1. Vaccines
     1. antigen
     2. antibody
     1. kinds of vaccines
     2. definition
     3. manufacturing
     4. successes
     5. bottom line
     6. production
     7. how different
     8. test for acceptability
  2. Antibodies
     1. polyclonal
        1. definition
        2. source
     2. monoclonal
        1. definition
        2. source
        3. uses
        4. production11.5 Biopharmaceuticals / therapeutic proteins
     3. compare & contrast most pharmaceutical products with biopharmaceuticals
     4. development requirements
     5. difficulties with protein based biopharmaceuticals
  3. Insulin
  4. Somatostatin
  5. Interferons
  6. Lymphokines
  7. Hematopoietic growth factors
• 11.6 Pharmacogenetics
  1. Definition
• 11.7 Molecular biology and human disease
  1. Biomarkers
• 11.8 Diagnostics in developing countries
• 11.9 Gene therapy
  1. Definition
  2. Goal
  3. Challenges
     1. delivery
        1. retro virus
        2. DNA virus
        3. direct injection
        4. lipofection
        5. Ab-like protein
     2. expression
  4. Results so far
  5. Cell type
     1. germ
     2. somatic
• 11.10 Systems biology and medicine
  1. Vision