Adrenal Hormones Chapter 27

1. Adrenal Gland
   1. Structure
      1. cortex
      2. medulla
2. Adrenal Cortex
   1. Zones
3. Mineralocorticoids
   1. Structure
   2. Aldosterone
   3. spironolactone (Aldactone)
      1. Conn's syndrome
   4. eplerenone (Inspra)
4. Glucocorticoids
   1. Cortisol
      1. metabolic actions
      2. permissive actions
      3. stress
      4. anti-inflammatory effects
      5. regulation
         1. CRH
         2. ACTH
   2. Therapeutic uses of corticosteroids
      1. replacement therapy
         1. Addison disease
            1. hydrocortisone
      2. too much
         1. Cushing syndrome
            1. diagnosis
               1. dexamethasone (Decadron)
            2. treatment
               1. ketoconazole (Nizoral)
         2. CAH - Congenital adrenal hyperplasia
      3. Relief of inflammatory symptoms
         1. Topicals
            1. betamethasone (Celestone, Diprolene, Luxiq)
            2. triamcinolone (Kenalog, Nasacort, Aristospan)
            1. conditions
         2. Oral
            1. methylprednisolone (Medrol)
            2. prednisolone (Orapred, Pediapred)
            3. prednisone
            1. conditions
         3. injection - intra-articular
         4. inhalation - see next chapter (section)
   3. Pharmacokinetics
   4. Adverse effects
   5. Discontinuation