Adrenal Hormones                   Chapter 27

   I. Adrenal Gland
      A. Structure
         1. cortex
         2. medulla

  II. Adrenal Cortex
      A. Zones

 III. Mineralocorticoids
      A.Structure
      B. Aldosterone
      C. spironolactone (Aldactone)
         1. Conn's syndrome
      D. eplerenone (Inspra)

  IV. Glucocorticoids
      A. Cortisol
         1. metabolic actions
         2. permissive actions
         3. stress
         4. anti-inflammatory effects
         5. regulation
            a. CRH
            b. ACTH
      B. Therapeutic uses of corticosteroids
         1. replacement therapy
            a. Addison disease
               1) hydrocortisone
         2. too much
            a. Cushing syndrome
               1) diagnosis
                  a) dexamethasone (Decadron)
               2) treatment
                  a) ketoconazole (Nizoral)
            b. CAH - Congenital adrenal hyperplasia
         3. Relief of inflammatory symptoms
            a. Topicals
                  a) betamethasone (Celestone, Diprolene, Luxiq)
                  b) triamcinolone (Kenalog, Nasacort, Aristospan)
               1) conditions
            b. Oral
                  a) methylprednisolone (Medrol)
                  b) prednisolone (Orapred, Pediapred)
                  c) prednisone 
               1) conditions
            c. injection - intra-articular
            d. inhalation - see next chapter (section)
   V. Pharmacokinetics
  VI. Adverse effects
 VII. Discontinuation