Antibiotics - Antimicrobial Therapy

   I. Background - Chapter 37
      A. Overview
         1. selective toxicity
      B.Empiric therapy
         1. culture
      C. Elimination
         1. bactericidal
         2. bacteriostatic
      D. Dosing
         1. concentration-dependent killing
         2. time-dependent killing
         3. postantibiotic effect
      E. Spectra
         1. narrow
         2. extended
         3. broad
      F. Resistance

  II. Inhibitors of Cell Wall Synthesis - Chapter 38
      A. Overview
      B. Penicillins
         1. resistance
            a. natural
            b. acquired
               1) beta-lactamases
      C. Cephalosporins
         1. generations
            a. 1st Generation
            b. 2nd Generation
            c. 3rd Generation
            d. 4th Generation
      D. Vancomycin

 III. Protein Synthesis Inhibitors - Chapter 39
      A. Overview
      B. Tetracyclines
         1. mode of action
         2. resistance
         3. notes
         4. elimination
         5. adverse effects
      C. Aminoglycosides
         1. mode of action
         2. resistance
      D. Macrolides
         1. mode of action
         2. resistance
      E. Chloramphenicol
         1. mode of action
         2. resistance

  IV. DNA Altering Drugs - Quinolones          Chapter 40
      A. Overview
         1. nalidixic acid
      B. Mode of action
      C. fluoroquinolones
      D. Resistance
      E. Elimination

   V. Folate Antagonists
      A. Background
         1. Folic acid
      B. Sulfonamides
         1. background
         2. mode of action
               1) PABA
         3. resistance
         4. elimination
      C. Trimethoprim
         1. mode of action
         2. resistance
      D. Bactrim