Estrogens and Androgens                      Chapter 26

   I. Overview
      A. Steroid hormones
         1. lipophilic
               1) nuclear receptors
            a. membrane receptors
      B. Physiology
      C. Medicinal uses

  II. Estrogens
      A. Estradiol
      B. Metabolites
         1. estrone
         2. estriol
      C. SERMs
         1. drugs
            a. tamoxifin
            b. raloxofene
            c. clomiphene
      D. Synthetic
         1. ethinyl estradiol
         2. mestranol

 III. Progestogens
      A. Progesterone

  IV. Contraceptives
               1.  adverse reactions
      A.Combination oral
         1. desogestrel 
         2. drospirenone
         3. levonorgestrel
         4. norethindrone
         5. norethindrone acetate
         6. norgestimate
      B. Transdermal patch
         1. norelgestromin
      C. Vaginal ring
         1. etonogestrel
      D. Progestin-only pills
         1. norethindrone
      E. Injectable
         1. medroxyprogesterone acetate
      F. Progestin implants
         1. etonogestrel
      G. Progestin intrauterine device - IUD
         1. levonorgestrel

   V. Emergency contraception
      A. High dose hormone
         1. progestin alone
            a. levonorgestrel
               1) Next Choice, Plan B
               2) PlanB One-Step
         2. progestin + estrogen
      B. Antiprogestin
         1. mifepristone = RU486
      C. Progesterone agonist/antagonist
         1. ulipristal acetate

  VI. Androgens
      A. Physiology
            a. testosterone
         1. other androgens
         2. effects
      B. Therapeutic uses
         1. danazol
      C. Pharmacokinetics
         1. derivatives
            a. fluoxymesterone
            b. oxandrolone
      D. Adverse effects
      E. Antiandrogens
         1. inhibit production
            a. finasteride
            b. dutasteride
         2. block receptors
            a. flutamide
            b. bicalutamide
            c. enzalutamide
            d. nilutamide