Drugs for Hyperlipidemia           Chapter 23

  I. Background
     A. Triglycerides
     B. Cholesterol

 II. Transport of lipids
     A. Background
        1. Lipoproteins
        2. Components
           a) apolipoproteins
        3. Differentiation
     B. Chylomicrons
        1. Structure / contents
           a. apoB-48
        2. Source / function
           a lipoprotein lipases
        3. Removal
     C. VLDL
           a. apoB-100
        1. Source / function
        2. Removal
     D. IDL
     E. LDL
        1. Source / function
        2. Removal
        3. Additional items
           a. hypercholesterolemia
     F. HDL
        1. Structure / contents
        2. Source / function

III. Statins
     A. Cholesterol synthesis
        1 HMG-CoA reductase
     B. Other effects
     C. Drugs
        1. atorvastatin
        2. simvastatin
        3. lovastatin
        4. pravastatin
        5. rosuvastatin

 IV. Other lipid lowering drugs
     A. Niacin
     B. Fibrates
        1. PPARs
        2. drugs
           a. fenofibrate
           b. gemfibrozil
     C. Bile acid-binding resins
        1. drugs
           a. cholestyramine
           b. colestipol
           c. colesevelam
     D. Cholesterol absorption inhibitor
        1. ezetimibe
     E. Omega-3 fatty acids