Migraine Treatments

   I. Background
      A. Types of headaches
      B. Migraines
           1. types
               a. without aura
               b. with aura
           2. physiology
      C. Management / Treatment
           1. avoid triggers
           2. abortive treatments
           3. prophylactic therapy

  II. Migraine Abortive Treatments
      A.    NSAIDs
      B. Serotonin agonists
           1. serotonin background
               a. discovery
               b. location
               c. effects
               d. synthesis
               e. receptors
           2. Triptans
               a. drugs
                   1) sumatriptan (Imitrex, Onzetre, Zembrace)
                   2) eletriptan (Relpax)
                   3) rizatriptan (Maxalt, Maxalt-MLT)
                   4) zolmitriptan (Zomig)
      C. Ergot alkaloids
               a. ergotamine (Ergomar)
               b. dihydroergotamine (DHE 45, Migranal)
      D. CGRP receptor antagonists
           1. background
           2. receptor antagonist
               a. ubrogepant (Ubrelvy)
               b. rimegepant (Nurtec)
      E. Opioids

 III. Migraine Prophylaxis Treatments
      A. beta-blockers
           1. propranolol (Inderal LA, Innopran XL)
      B. Anticonvulsants
           1. topirmate (Topamax)
           2. valproic acid (Valproate)
      C. Other
      D. CGRP
           1.  CGRP itself
               a. monoclonal antibodies
                   1) fremanezumab (Ajovy)
                   2) galcanezumab (Emgality)
                   3) eptinezumab (Vyepti)
           2. block receptor
               a. monoclonal Ab
                   1) erenumab (Aimovig)
               b. receptor antagonist
                   1) rimegepant (Nurtec)
                   2) atogepant (Qulipta)
      E. Antidepresents
           1. tricyclic antidepressants
               a. amitriptyline (Elavil, Endep, Vanatrip)
               b. nortriptyline (Pamelor)
           2. SNRI
               a. venlafaxine (Effexor ER, Effexor)
           3. SSRI
               a. fluoxetine (Prozac, Sarafem, Rapiflux, Selfemra)

  IV. Tension Headaches

   V. Cluster Headaches