Drug-Receptor Interactions & Pharmacodynamics Chapter 2

1. Pharmacodynamics
   1. receptor
   2. ligand
   3. agonist
   4. antagonist
2. Signal Transduction
   1. Receptors
      1. ligand-gated ion channels
      2. G protein-coupled receptors
      3. enzyme-linked receptors
      4. intracellular receptors
   2. Characteristics of signal transduction
      1. amplification
      2. desensitization
3. Dose-Response Relationships
   1. Measurements
      1. ED50
      2. EC50
      3. IC50
      4. LD50
      5. LC50
      6. TD50
      7. MM curve
   2. Potency
   3. Efficacy
4. Intrinsic Activity
   1. Agonists
      1. full agonists
      2. partial agonists
      3. inverse agonists
   2. Antagonists
      1. competitive antagonist
      2. irreversible antagonists
      3. allosteric antagonists
5. Quantal Responses
   1. Therapeutic index (TI)