Drug-Receptor Interactions & Pharmacodynamics                    Chapter 2

   I. Pharmacodynamics
         1. receptor
         2. ligand
         3. agonist
         4. antagonist

  II. Signal Transduction
      A. Receptors
         1. ligand-gated ion channels
         2. G protein-coupled receptors
         3. enzyme-linked receptors
         4. intracellular receptors
      B. Characteristics of signal transduction
         1. amplification
         2. desensitization

 III. Dose-Response Relationships
      A. Measurements
         1. ED50
         2. EC50
         3. IC50
         4. LD50
         5. LC50
         6. TD50
         7. MM curve
      B. Potency
      C. Efficacy

  IV. Intrinsic Activity
      A. Agonists
         1. full agonists
         2. partial agonists
         3. inverse agonists
      B. Antagonists
         1. competitive antagonist
         2. irreversible antagonists
         3. allosteric antagonists

   V. Quantal Responses
      A. Therapeutic index (TI)